Computational science in drug metabolism and toxicology

Editorial: Drug Metabolism and Toxicology

A drug metabolism study is an important aspect of the early drug discovery and development process [1,2]. In order to improve the understanding of drug efficacy and safety characteristics, it is desirable to investigate the drug metabolism in animals or humans [3,4]. These metabolism studies involve metabolic stability, cytochrome P-450 (CYP-450) induction or inhibition and metabolite identific...

In silico approaches to predicting drug metabolism, toxicology and beyond.

The discovery and optimization of new drug candidates is becoming increasingly reliant upon the combination of experimental and computational approaches related to drug metabolism, toxicology and general biopharmaceutical properties. With the considerable output of high-throughput assays for cytochrome-P450-mediated drug-drug interactions, metabolic stability and assays for toxicology, we have ...

SNP communications: coalition of toxicology and drug metabolism and pharmacokinetics.

Drug and Chemical Toxicology

In the present study, the genotoxic effects of the low-calorie sweetener aspartame (ASP), which is a dipeptide derivative, was investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test, micronucleus test in human lymphocytes and also Ames/Salmonella/ microsome test. ASP induced CAs at all concentrations (500, 1000 and 2000 mg/ml) and treatment periods (24 and 48 h...

A Bibliometric Analysis of Toxicology Publications of Iran and Turkey in ISI Web of Science

Background: Web of Science (WoS) is an online academic citation index provided by Thomson Reuters which supplies valuable bibliometric information for comparing impact of specific author, organization, or country in science production. The aim of this study was to compare toxicology publications of Iran and Turkey indexed in WoS from bibliometric point of view. Methods: The WoS database was ...